Could history's two most notorious killers actually be the same man? Jeff Mudgett, great-great-grandson of America's first serial killer and expert con man, H.H. Holmes, and ex-CIA operative Amaryllis Fox team up to investigate the theory that Holmes was Britain's infamous murderer, Jack the Ripper.

Myths about the Ripper are challenged while trying to connect H.H. Holmes to Jack the Ripper.

An unexpected link to H.H. Holmes is found in the letters of Jack the Ripper. Scotland Yard's list of credible suspects gives some details for the manhunt.

An investigation into the murder house shows that Holmes may have killed all over Chicago and beyond. Meanwhile, a report surfaces that the Ripper may have killed in the US.

While investigating Chicago's World Fair of 1893, an unexpected connection to Jack the Ripper is found in the police archives.

Holmes is on the run after too many failed schemes but the investigation picks up the trail. A long lost crime scene may hold the clue to whether Holmes is the Ripper.

A trove of artifacts contain an unexpected link to the UK. While investigating Holmes' last days on the lam, Jeff and Amaryllis discover the Holmes curse and a legend that the killer escaped his death.

The crew look to prove that Holmes pulled off one last swindle, escaping his own execution. Holmes' grave site is exhumed to see what it reveals.