Columbus' voyage is a success but a storm forces him to land on Portugal. The royals travel to Barcelona to sign a treaty with France, who ambitions to conquer Naples. The queen meets her new confessor, and her daughter ponders her future.

Columbus hides his doubts as he is pressed to make a second voyage. Portugal disputes the new lands to Castile, and France invades Italy. In Rome, the Pope juggles the rival countries interests for his own benefit.

Colombus has gone missing, and word travels back that his brothers are abusing the natives. Desperate to defeat the French, Isabel and Ferdinandmust decide whether to use their children tools in their tactical negotiations.

Queen Isabel copes with loss on multiple levels, including Princess Juana's departure for Flanders to live with her husband.

Margarita arrives in Castile to marry Juan, a union that will bring equal parts joy and devastation.