Mark and Eleanor return to New York City, hoping to find a cure for a rare affliction. Naomi tries to balance investigating a brutal murder at work with raising her son Isaiah. Claire receives a devastating call from her estranged father.

Mark chases down a lead that might help him finally discover a cure for Eleanor. Naomi discovers an unsettling pattern to the string of local murders. Claire is forced to make an all-important decision about her future.

Upon learning that Naomi is a homicide detective, Mark covers his tracks. Eleanor discovers that Isaiah is being bullied and seeks revenge. Naomi and Ben make a massive discovery. Claire is on the brink of a major breakthrough.

Mark and Zeke's celebration of the restaurant's tenth anniversary ends with an unexpected bang. Eleanor and Isaiah sneak out for a night of wonder and danger. Naomi struggles with new developments in her case. Claire makes great strides.

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