Patagonia, 1960. A German physician meets an Argentinean family and follows them on the long desert road to Bariloche where Eva, Enzo and their three children are going to open a lodging house by the Nahuel Huapi lake. This model family reawakens his obsession with purity and perfection, in particular Lilith, a 12 year-old with a body too small for her age. Unaware of his true identity, they accept him as their first guest. They are all gradually won over by this charismatic man, by his elegant manners, his scientific knowledge and his money — until they discover they are living with one of the biggest criminals of all times.

Set in Catalonia, Painless weaves two stories: in one, starting during the Spanish Civil War and running through to the '60s, an asylum attempts to rehabilitate children who feel no pain, by teaching them physical suffering. In the second, in the present time, a brilliant neurosurgeon who needs a bone marrow transplant, discovers this dark past when he searches for his biological parents.

Petra doesn’t know who her father is. Her entire life, it’s been hidden from her. After the death of her mother, she embarks on a search that leads her to Jaume, a famous artist and a powerful, ruthless man. On her path to uncovering the truth, Petra also meets Jaume’s son, Lucas, as well as Marisa, his mother and Jaume’s wife. That is when the story of these characters begins to intertwine in a spiral of malice, family secrets and violence that drives them all to the edge. But fate’s cruel logic is derailed by a twist that opens a path to hope and redemption.

The drama is centered around four friends and business partners who in one evening are forced to find a way to save their company and themselves. The impossible decision they face is agreeing on who will be the one to sacrifice their freedom to save the others from personal and financial demise. It is a race against time that will put their friendship and sanity to the test. Who will take the fall?