Fowl-mouthed villain Turkie carves through the likes of a rapping grandma, a mindless puppet, a wig-wearing inventor, a bisexual space worm, and their equally ridiculous friends on his quest to recover the last copy of "ThanksKilling 2". Also known as "Turkeys, In, Space!".

In order to save her siblings, a young woman takes on her father and the powerful entity known as Gamemaster, who ensnares humans into diabolical plots while her species gambles on the outcome.