It's 1905 when 12 year old Sophia plays all by herself in her big, creepy house with only four handmade dolls as friends. When her abusive father has finally had enough, he forces her to bury them in the backyard. But, after she "slips" and breaks her neck, dad buries her right along with the dolls. 100 years later, the Fillbrook family moves into the very same house.

When Cassie flees an abusive relationship, and falls victim to a moon-worshiping 600 year old Romanian Countess; a troubled paranormal investigator of Native American heritage finds himself in a deadly love triangle with a battered-woman werewolf.

Thanks to an auto accident, a parasitic alien manages to get into a hospital. It quickly moves from the crash victim into a candy striper. Among the patients at the hospital are some rather short high school basketball players. It is through them that we watch the events unfold. The infected, or inhabited, candy striper becomes predatory. She goes after men for sex and after women to spread. Infected women develop an incredible sweet tooth and devour anything sweet they can find. The horror then spreads. As the horror takes over more of the hospital and the CDC locks it down, the basketball players and a few friends do everything they can to try and get out of the hospital. But soon it becomes evident that the problem has spread too far. Now if they manage to escape it will only be to delay the inevitable if they cannot halt the spread of aliens before they get out and take over the whole world.