While working on a science project, high school student Cleo accidentally creates a vapor that turns a moth invisible. But that's not the only thing she turns invisible; she finds out she also turned her older sister invisible. With her sister invisible and only hours to find a cure, Cleo must use her friends and her skills to cure her invisible sister.

An optimistic ex-con reinvents himself as an alternative medicine doctor with hopes of impressing his family. But his plans go awry, and soon everyone's embroiled in this comedy of errors set in the heart of Cajun Louisiana.