An AWOL soldier with PTSD goes into hiding. Along with his brother and a few friends they retreat into a rural farm area unaware that the outside world has stopped functioning. On their way back to civilization, his brother is attacked and bitten by an infected farmer. The brother quickly turns into a rabid animal and lives for exactly three hours. Realizing that they are in grave danger, they head back to the forest trying to outlive the legions of the infected.

A prime-time network news magazine show premieres controversial leaked footage from a highly-classified U.S. government program named Nocturne Six that recruits citizens with extrasensory abilities. Forced into the program by unscrupulous means, these gifted, yet apprehensive citizens, known as "guardians", are sent to parallel planes of Earth in order to thwart imminent attacks by dangerous supernatural entities. A live investigation by the news show at the abandoned site of the Nocturne Six program quickly devolves and exposes the unearthly evils that the guardians faced in their treacherous missions.