After a stagecoach is robbed and the passengers murdered, a long and tangled series of surprise attacks and murderous double-crosses, leaves the coach's strongbox in the hands of the killer Lasky. It is up to the legendary hero Sartana to track down the missing money and determine just who is ultimately behind the grisly robberies and killings.

Wily roving gunslinger Sartana arrives in a small town and tries to find a hidden fortune of half a million dollars in gold and two million dollars in counterfeit money. Naturally, a bunch of other treacherous folks who include conniving widow Senora Manassas, shrewd fellow gunslinger Grand Full, and the vicious and unhinged General Monk are also looking to get their greedy hands on said fortune.