On the eve of her college graduation, Natalie's life diverges into two parallel realities: one in which she becomes pregnant and must navigate motherhood as a young adult in her Texas hometown, the other in which she moves to LA to pursue her career. In both journeys throughout her twenties, Natalie experiences life-changing love, devastating heartbreak and rediscovers herself.

Vic and Melinda Van Allen are a couple in the small town of Little Wesley. Their loveless marriage is held together only by a precarious arrangement whereby, in order to avoid the messiness of divorce, Melinda is allowed to take any number of lovers as long as she does not desert her family.

The Dog House is a legendary New York dive bar, owned by an extraordinary family. Three people, from different back grounds, enter at closing time on separate nights, carrying the world on their shoulders; but by the time each of them leaves after "last call", their souls are saved, while two of them realize how connected they are.