Two self-involved cousins have better things to do than embark on a road trip with their grandmother, Gloria. But someone has to take the frail woman to an assisted care facility. Despite such inconvenient circumstances, the two cousins - a risk-averse yuppie and a slacker stand-up comedian - find plenty of laughs along the way.

When a down-on-his-luck inventor builds a time machine to change the past, he unwittingly sets off a disastrous chain of events.