A bored house cat who longs to explore the outside world escapes his home after he mysteriously transforms into a human.

After the death of his wife, a grieving man becomes the victim of a horrific experiment to cure his addiction.

On a desolate stretch of desert highway, weary travelers - two men on the run from their past, a band on their way to the next gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation - are forced to confront their worst fears and darkest secrets in a series of interwoven tales of terror and remorse on the open road.