Blood Brother takes place on the mean streets of a city in decay, where a recently released convict begins to take murderous revenge against his childhood friends, whom he believes let him take the fall for a crime they collectively committed. As the bodies start piling up, one of the friends, now a cop, will stop at nothing to put an end to the murderous rampage and to right the many wrongs of their tragically violent past.

A grifter indebted to a New Orleans gangster thinks he can make a killing and win back his money-troubled ex-lover with the help of a bank robbery already set to go down. The reunited lovers team up for the job, but get caught in a whirlwind of danger as the robbery turns deadly.

Johnny, an aspiring bodybuilder from Boston leaves behind his troubled past and heads to LA in hopes of training with his mentor from YouTube. His plans are quickly derailed by a shady porn director and a lifelong friend who is a murderous drug runner.