Liza is a young Dutch woman who travels to Venice to meet her Italian father Mauro. Mauro has not seen Liza since she was three years old, when he and Liza’s mother decided to split up. Mauro has traveled the world since as a musician. When Liza is in Venice it turns out there is more in store than just a couple of days in Venice. He takes Liza on a musical voyage along the route of the Orient Express. A trip that will eventually take them to Istanbul.

Masha is in an overwhelming relationship with Luuk, father of two and divorced. Nothing seems to stand in their way until Luuk becomes incurably ill.