Under the watchful eye of his mentor Captain Mike Kennedy, probationary firefighter Jack Morrison matures into a seasoned veteran at a Baltimore fire station. Jack has reached a crossroads, however, as the sacrifices he's made have put him in harm's way innumerable times and significantly impacted his relationship with his wife and kids. Responding to the worst blaze in his career, he becomes trapped inside a 20-story building. And as he reflects on his life, now Deputy Chief Kennedy frantically coordinates the effort to save him.
Pandemic is set in the near future, where a virus of epic proportions has overtaken the planet. There are more infected than uninfected, and humanity is losing its grip on survival. Its only hope is finding a cure and keeping the infected contained. Lauren (Rachel Nichols) is a doctor, who, after the fall of New York, comes to Los Angeles to lead a team to hunt for and rescue uninfected survivors.
As the heir and current marketing director for one of the nation's biggest gun manufacturers, Liberty Wallace is indifferent to the atrocities made possible through her business and her CEO husband, Victor. On her way to see her actor lover, Liberty ends up chained to a food cart full of explosives -- all at the insistence of "Joe", a sniper whose young daughter was a victim of gun violence, and who now has Liberty in his sights.
Impatient to have a child, an infertile couple seeks help at a sperm bank and are thrilled when the procedure works. But their joy is cut short after they discover the donor is a psychopath willing to kill anyone who stands between him and his baby.