Tommy and EJ are brothers with nothing in common. Tommy is a straight A student who desperately wants to be cool and EJ is a former high school legend living at home, wasting away in middle management in GE's innovation lab with dreams of becoming the next Mark Zuckerberg. When Tommy and EJ's parents leave town for their second honeymoon, the boys join forces to throw a legendary high school party with hopes of making Tommy the king of his class and EJ the next great app developer.

Before their eventual team-up with Scooby and the gang, bright and optimistic Daphne and whip-smart and analytical Velma are both mystery-solving teens who are best friends but have only met online - until now. Daphne has just transferred to Velma's school, Ridge Valley High, an incredible tech-savvy institute with all the latest gadgets provided by the school's benefactor, tech billionaire Tobias Bloom. And while competition is fierce among the students for a coveted internship at Bloom Innovative, Daphne and Velma dig beyond all the gadgets and tech to investigate what is causing some of the brightest students in school to disappear - only to emerge again in a zombie-fied state.