A filmmaker facing an existential crisis goes on a vacation to a Mexican gay nudist beach, where he meets a social media celebrity who convinces him to collaborate with him on his new TV show. But one disappears and another embarks on a wild journey through Mexico City to find him.

Jamie (Cera) is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman -- a radical spirit named Crystal Fairy (Hoffmann) -- to come along. What is meant to be a devil-may-care journey becomes a battle of wills as Jamie finds himself locking horns with his new traveling companion. But on a remote, pristine beach at the edge of the desert, the magic brew is finally imbibed, and the true adventure begins. Written by Production

A close-knit trio navigates the idea of creating life, while at the same time being confronted with a brutal scenario that causes them to take a life.