One year after running away from home, Nicole and Jesse are still missing. When Jesse's brother, Tom, returns home from active duty, he sets out with his friends Marilyn and Jared to locate the lost couple. Their search leads them to the stretch of old highway with a mysterious Rest Stop, where they find themselves in the same predicament as Nicole and Jesse: confronting a madman.

Two down and out strangers are brought together by mysterious letters into a safe house as the world around them is infected by an experimental virus that transforms the living into the living dead. She is a former prostitute hiding from the world. He is a former assassin turned priest who has renounced violence. Together they must unravel the mystery of the letters if they hope to survive.