The beauty transgender Erika arrives in an old house in the country during a stormy night. She is escaping from her violent boyfriend. At first Erika find peace, but day by day strange things begin to happen: voices, shadows - And a man of the nearest village says to Erika that the house is known in the village as "The house of murderers" since the Second World War.

Rome is shattered by a series of gruesome murders that paint the Eternal City deep red. The suspicion grows that these atrocious crimes are connected with the return of one of the most heinous serial killers of our time - Karl the Butcher.