The film focuses on the tumultuous romance in the lives of four women in The Hague. Teenage daughter Eva, her mother Judith, aunt Barbara and older sister Anna make it under one roof Hague together a nice game of. They are beautiful, courageous and sensible, but sometimes they just do not know in a world full of tender love, serial dating, slaked lust, affairs, children's desires and indestructible old loves.

Hartenstraat is set in the Nine Streets district of Amsterdam. It is a village in a big town and everyone seems to be looking for love. As the womanizer Bas, seniors Bep and Aart and the couple Rein and Jacob. The only one who is not looking for love is Daan. He lives here with his daughter Saar in Hartenstraat, where he has his own business as a caterer. Then Katje appears in his life. The pretty fashion designer opens a fashion boutique next door to Daan. When her catering unexpectedly cancels just before opening her shop Katje must appeal to Daan. That is asking for trouble since the two opposite each other in everything. Yet Katje also secretly has an eye on her neighbor, especially now that her current relationship with Thomas is not going strong.