Haunted by memories of his ex-girlfriend Alice, a heartbroken Billy returns home to Northern Virginia seeking solace from old friends. But what he finds there is more disconcerting: his best friend Stanley has become unstable, mysterious and withdrawn from those around him. Billy teams up with another old friend to find out what's going on and as they probe Stanley's recent activities, their friend's behaviour seems more and more bizarre and frightening.

In this darkly karmic vision of Arizona, a man who breathes nothing but ill will begins a noxious domino effect as quickly as an uncontrollable virus kills. As he exits Arizona State Penn after twenty-one long years, Wilson has only one thing on the brain, leveling the score with career criminal, Mackey Willis.