When Harvard PhD student Jennifer Brea is struck down at 28 by a fever that leaves her bedridden, doctors tell her it's "all in her head." Determined to live, she turns her camera on herself and her community, a hidden world of millions confined to their homes and bedrooms by ME, commonly called chronic fatigue syndrome.

The world-famous house that inspired the Conjuring film has recently been sold and is now open to paranormal investigations. With special access, a small group of filmmakers and paranormal investigators are allowed to move into the famously haunted home for two weeks in hopes of capturing evidence. During this time the group will be experiencing, investigating, and documenting every moment. Will they be able to make it through their stay? Do malevolent spirits still haunt this home, or is it something more sinister?