Series is based on what Maria has accepted to be her life. The occasionally surreal episodes, refracted across multiple periods of the actor/comedian's life, tell the story of a woman who loses - and then finds - herself.

Nina is a dedicated, career driven corporate attorney who has a very public nervous breakdown after getting passed up for an expected promotion and now finds herself working as a public defender. Her personal and professional worlds are turned upside down when she joins the ranks of the legal world’s underdogs and very quickly realizes that the law isn't quite as fair as she once thought.

Doctors Owen Maestro and Lola Spratt leave Children's Hospital and join a secret arm of the CDC to investigate and destroy a deadly global virus.

Doctors Owen Maestro and Lola Spratt leave Children's Hospital and join a secret arm of the CDC to investigate and destroy a deadly global virus.

An overconfident female head-of-a-household struggles to regain a higher status for herself, and for her family of oddballs, after losing her job and moving from the rich side to the poor side of an Arkansas small town. To save money, they’ve moved into their inherited Victorian fixer upper, the historic Harper House.