Three years later; CTU receives a threat that Mexican drug lord Hector Salazar is planning on releasing a deadly contagious virus in LA unless Jack gets his brother Ramone Salazar out of prison. President Palmer prepares for a presidential debate with Senator John Keeler. Written by Derfel85

An hour after an infected body is dropped off at the CDC Jack and Chase begin to trace its last known locations while CTU tracks down drug dealers in East LA. President Palmer considers canceling the debate. Chief of Staff Wayne Palmer presents the President with an unethical solution in dealing with Senator Keeler. Written by Derfel85

Tony and one of Salazar's cronies close in on a young drug trafficker who may be unknowingly carrying the virus. Jack informs Kyle Singer's parents that he may be infected. Wayne becomes concerned over David's latest affair when he learns the woman's ex-husband will perjure himself over sworn testimony he gave years earlier unless the President pays him not to. Written by Derfel85

Jack asks for President Palmer's permission to go deep undercover and get Ramon out of prison after CTU looses track of Kyle Singer. While Jack prepares to get Ramon out under the cover of a prisoner transfer Chase disobeys orders and goes to confront Ramon himself. President Palmer calls off Wayne's meeting with Anne's ex-husband. Written by Derfel85

Jack and Ramon are captured by dangerous prison inmates after trying to escape. President Palmer begins his debate with Senator Keeler. At CTU, Chloe O'Brian discovers evidence of Jack's heroin addiction.

Jack and Ramon try evade military helicopters when they make a run for a plane scheduled to leave for Mexico. Palmer cancels the debate. Kyle Singer learns that he is not infected with the virus. Kim discovers that Gael Ortega might be working with the Salazars. Written by Derfel85

Ramon holds Jack hostage as they fly down to Mexico. Regional Director Chappelle interrogates Gael; Tony returns prematurely to CTU to reveal Gael's true allegiance. Chase disobeys orders and heads for Mexico to rescue Jack.

Jack tries to regain the Salazars' trust when they make it to Mexico. President Palmer is angry with Tony over being left out of a secret operation. Chase is captured by Salazar's men.

A snag in the sale of the virus leads the Salazars to question Jack's motivations and as a result they put his allegiances to the test. Claudia works to help Chase escape after Jack informs her of his real priorities. Tony's ability to run CTU is called into question. Palmer is put into a difficult position regarding his brother. Written by Patrick Gurney

In order to get closer to the virus, Jack tries to make Nina believe he still has feelings for her. Wayne tries to gain the trust of Julia Milliken when Alan Milliken starts making demands. Chase convinces Salazar's girlfriend to help him escape. Written by Derfel85

Jack and Nina prepare to meet with Amador, the man selling the virus; CTU organizes an ambush. Ramon and Hector have a falling out. President Palmer asks his ex wife Sherry to help with the Milliken situation.

Jack and Nina are double-crossed when Ramon steals the virus during the exchange with Amador. Sherry gains a short-lived advantage in dealing with Alan Milliken.

When she's captured by Jack and Chase, Nina unleashes a self repeating worm in CTU's computer system that cuts off inter-agency connectivity and endangers undercover CTU operatives around the world. Sherry runs out of options and decides to break into Alan Milliken's house and steal his cell phone in order to get incriminating evidence. Written by Derfel85

Regional Director Chappelle forces Jack to undergo a medical evaluation for his heroin addiction. Tony interrogates Nina Meyers. Julia Milliken confronts Sherry after Alan dies while Wayne and President Palmer prepare for the fallout. Nina tries to escape custody after collapsing during the interrogation.

Amador and his people receive orders from their client to release the virus in the Chandler Plaza Hotel. Jack closes in on Amador but it's too late. Michelle and Gael alert the Chandler's Chief of Security to the dangers of the threat.

After the interrogation goes nowhere, Jack and Chase let Amador escape hoping he will lead them to his client's location. Michelle places the hotel under quarantine and must make a difficult decision in how to handle the ensuing panic. President Palmer is put into a awkward position when handling the Milliken situation. Written by Derfel85

President Palmer gives into Stephen Saunders's strange demand of placing an seemingly nondescript phrase into a speech in the hopes of delaying another viral outbreak. Michelle takes control of the situation inside the hotel. Jack and Chase bring a suspect to the local branch of MI-6 as Saunders launches an attack on the building.

Jack has to comply with another one of Saunders' demands: the death of Regional Director Ryan Chappelle. Michelle discovers that one of the infected hotel patrons got out before the quarantine was enforced.

Jack learns that Saunders' has a daughter attending a local LA college and that the only possible match for a bait and switch operation is his daughter Kim. Palmer informs his cabinet of the dangers the nation is facing. Chase tracks down the man who left the hotel quarantine as the virus spreads among the general public. Written by Derfel85

Jack uses Saunders' daughter as leverage in attempt to control the virus. Palmer maneuvers around a confused and angry press. Michelle awaits the result of a test to see if she is infected. Saunders starts making demands of Tony after capturing Michelle. Written by Derfel85

Tony works covertly to find a way to get Janes Saunders out of CTU and deliver her to Saunders before Jack and Chase find him. Senator Keeler receives some damaging information on President Palmer from a surprising source.

Jack and Tony clash as they wait for the time of hostage exchange with Saunders. Senator Keeler confronts President Palmer about the Milliken cover-up while Wayne initiates a secret operation against Sherry.

Jack and Chase try to track down the location of vials containing the virus. Wayne breaks into Sherry's house to get incriminating evidence as a paranoid Julia Milliken confronts Sherry.

Jack and Chase corner Saunders' henchman Arthur Rabens in an active public school. Tony faces losing command of CTU and treason charges for saving Michelle. An emotionally broken President Palmer decides to drop out of the race for reelection. Written by Derfel85