In the season premiere, fresh off being fired last season by Blake, the Childrens Hospital doctors find new jobs and intense challenges at a crosstown hospital run by the stern Dr. Kids (guest star BETSY BRANDT - Breaking Bad). Meanwhile, Blake turns to a life of crime with his no-good brother, Sir Tinklebutton (guest star PAUL SCHEER - The League).

A rare disease appears at Childrens Hospital, and the team has to journey into the buried remains of the original Childrens Hospital with Val's alter-ego, Derrick Childrens, to find the cure. Meanwhile, the rest of the doctors desperately try to save the hospital's landmark millionth patient.

When Sy finally gets tenure, he decides to use its powers for the greatest good: building the world's first consumer jetpack. Elsewhere, Chief is stranded on a dance pedestal, and Owen learns just how hard it is to be the hospital DJ.

Set four years ago, Nurse Beth's origins are uncovered as we explore the world of the Nurses' Quarters in the Childrens Hospital basement. Beth has to navigate the complex social hierarchy of the nurses and avoid losing their friendship when she suddenly gets promoted to doctor.

In a Behind the Scenes episode, actor Just Falcon (who plays Dr. Glenn Richie) invites the rest of the Childrens Hospital cast to his special photography exhibition, where all of their shocking secrets are revealed. MOLLY SHANNON (Saturday Night Live) guest stars.

Blake, Lola and Glenn are excited to be attending this year's Doctor of the Year Convention (or DOY) in Vegas. Even though Blake has won six years in a row, Glenn and Lola are determined to win. Owen tags along to visit his mom, with surprising consequences.

After discovering that Childrens Hospital is out of tongue depressors, Owen finds himself embroiled in a dangerous hospital-wide conspiracy that reaches all the way up to Governor Jasper Ruth, the Boss Tweed of Sao Paulo, Brazil. GEORGE WENDT guest stars.

A race horse is wanted by fearsome mob boss Mamma Fiorucci, so Chief hides the animal in the hospital, all while Lola's college barbershop quartet tempts her into rejoining and Glenn glues Blake's hands into his latex gloves. VALERIE HARPER and WILL SASSO guest star. Recurring guest star BRIAN HUSKEY also appears.

Owen discovers that the fluid in Chief's hump tastes exactly like Coca Cola. Despite Chief's protests, Owen attempts to monetize her hump cola, while Blake suspects Glenn has an addiction problem and takes him to Nils Vildervaan, professional rehabilitationalimist. MICHAEL SHOWALTER guest stars.

A look back at an episode of the popular 1950s variety show The Show You Watch, known for its irascible host, hilarious skits and elaborate dances, but mostly revered for its weekly visit to Childrens Hospital, the sketch upon which the present day show is loosely based.

When Dr. Cat Black has a crisis of faith, the hospital's resident spiritual leaders fiercely compete against each other to convert her and win a monthly sales prize. Glenn grows frustrated that he isn't getting the respect he deserves for playing second bass in the L.A. punk band X. Guest stars include the band X (DJ BONEBRAKE, EXENE CERVENKA, JOHN DOE and BILLY ZOOM), along with JASON ANTOON, TOM ARNOLD, DICK CAVETT, RANDALL PARK and ALAN SMYTH.

It's Bring Your Grandparents to Work Day at the hospital. The doctors struggle with their grandparents, whether they're overbearing, trying to kill themselves or are just famous actors. BARRY BOSTWICK guest stars.

When Glenn and Owen experience bizarre hallucinations and Lola fears she's being followed by an imaginary doctor, they think a gas leak in the hospital might be to blame. But what they discover threatens to upset the entire future of Childrens Hospital.... ZANDY HARTIG, BRIAN HUSKEY and ANNE-MARIE JOHNSON guest star.