At Angels Memorial Hospital, Dr. Neal Hudson must constantly question the decency of extreme methods used by obsessive training program chief Leanne Rorish, who is trusted and protected by the chief of staff, and cleans up her insensitive messes in patient report. Luckily for the staff, nursing chief Jesse Sallander manages to translate and explain explicit ad implicit instructions. Angus Leighton excels technically, but seriously lacks confidence, while Malaya Pineda's cocky attitude needs reining in, but they make a fine team, while composed Mario Savetti simply does well. Late calling Christa Lorenson is expelled for blatantly ignoring instructions, yet redeems herself by spotting a fatal risk just in time, and discovers a motivational bond with Rorish. Written by KGF Vissers

Christa begs Neal to perform a surgery that will ensure a patient's reproductive future; a patient fights with Mario.

Amid the chaos and exhaustion of working 36 consecutive hours in Code Black, the doctors must deal with Margaret O'Brien (Gail O'Grady), the distraught mother of two sons who are in a devastating car accident. Also, Mario bullies Angus into performing an unnecessary operation but lets Angus take the blame when Leanne finds out.

A new surgical attending Cole Guthrie (Cress Williams) joins Angels Memorial with the help of his estranged father and clashes with Leanne over their contrasting approaches to medicine. Also, Christa has a crisis of confidence in the middle of a procedure on her first infant since the loss of her son.

Neal clashes with his father, Dr. Peter Hudson (Daniel Gerroll), who is a neurosurgeon, over how to treat his gravely ill mother, Asra Hudson (Roma Chugani), whose mysterious symptoms force Angels Memorial to quarantine Trauma One.

Leanne must deal with the difficult decision of whether to save Tom Moreno (Michael Trucco), the police officer who helped her during her family's accident, or his shooter, who has more serious injuries. Also, when Malaya's pregnant ex-girlfriend, Carla Niven (Shiri Appleby), arrives at the hospital with pain in her arm, Malaya is shocked by her MRI results.

Angus uses his background in psychology to help a woman who doesn't remember how she injured herself and others. Also, when Christa bonds with an illegal immigrant whose son is diagnosed with cystic fibrosis, she becomes determined to help the woman find long-term care for her son in the U.S.

Christa has her busiest shift yet when she is responsible for all emergencies at Angels Memorial that occur outside of the E.R. Also, Mario bonds with an older gay patient with a heart arrhythmia who's living with HIV (Stephen Spinella), Malaya starts a bone marrow drive for Carla (Shiri Appleby) and Leanne refuses a date with Cole (Cress Williams).

When the lead actor (Alton Fitzgerald White) of the musical The Lion King tour arrives at Angels Memorial with a throat infection, Leanne gives him a diagnosis that puts both his career and life in jeopardy. Also, the doctors and the cast of The Lion King help a 17-year-old boy deal with the difficult decision of taking his father off life support.

Leanne is rattled at the thought of losing Jesse as he fights for his life after suffering a massive heart attack. Also, Mario asks the residents to cover for him when he searches the city for a patient's son, disobeying Neal's direct order not to leave the hospital. Cress Williams returns Cole Guthrie.

The doctors find their own lives in danger when they arrive at the scene of a massive multi-vehicle accident on a highway covered in thick fog. Also, Jesse's confidence is shaken following his heart attack, while Carla's (Shiri Appleby) condition becomes critical.

As the doctors treat patients from the chaotic multi-vehicle accident, a love triangle begins to build between Mario, Angus and Heather. Also, when Malaya learns that Carla is at the hospital, she goes against Carla's wishes and stays by her side during the delivery of her baby.

Angus' older brother, an all-star ER doctor (Tommy Dewey) returns to Angels Memorial in hopes of securing a position as an attending and Christa's romantic feelings towards Neal begins to grow. Also, Malaya has to deal with a patient, Gordon Heshman (Jesse Bradford) who becomes obsessed with her.

Leanne visits a prison to confront the drunk driver who killed her family; a patient makes Malaya feel uncomfortable.

The doctors are questioned following a violent incident inside the hospital that leaves two doctors gravely injured. Also, Neal and Christa make their relationship to the next level after officially disclosing their romantic relationship to HR.

Christa becomes insecure in her new relationship with Neal when his ex-girlfriend, Dr. Grace Adams, returns to Angels Memorial after spending a year volunteering in Haiti. Also, New York Giants Pro Bowl wide receiver Odell Beckham Jr. comes to the ER to convince his stubborn high school football coach, Pete Delaney, to have life-saving surgery.

Christa must put aside her personal feelings for Grace and work with her to treat Brody, (Cameron Boyce), a patient who claims to have been abused at a camp for troubled teens. Also, Grace is surprised when Campbell asks her out.

Mario confronts Angus about his Adderall abuse and Christa is surprised to learn how romantically involved Neal and Grace were before she left for Haiti. Also, Dr. Mark Taylor (Kevin Dunn) returns to help Leanne find the money in their budget to keep Jesse and the nurses from walking out.