While looking for a way back to Earth, the Hulks discover the Leader stowed away on board the ship. Retribution must wait as the Agents of S.M.A.S.H. have to fight Ronan the Accuser and his Kree soldiers to save an old foe: Ego the Living Planet. But when Galactus comes to consume Ego the Living Planet, the Agents of S.M.A.S.H. must put themselves at risk to save the lives of their two enemies.

The Agents of S.M.A.S.H. must work together with Ego the Living Planet to fight with Galactus and his latest herald Firelord.

On Halloween, the Agents of S.M.A.S.H. encounter Nick Fury's Howling Commandos where they have been sent by Nick Fury to apprehend the Agents of S.M.A.S.H. The Howling Commandos have a change of plans when they end up helping the Agents of S.M.A.S.H. prevent Dormammu from breaking into Earth's dimension and turning all of humanity into Mindless Ones.

The Hulks must face each of their greatest fears in order to stop the Null from crossing through a worm hole to reap ruin upon Earth.

Upon being lured to an unnamed planet, the Agents of S.M.A.S.H. team up with their old friends the Guardians of the Galaxy to stop Super-Skrull and the Skrulls from using the Agents of S.M.A.S.H.'s gamma energy to create gamma-powered Skrulls in their latest plot to invade Earth.

The Hulks finally return to Earth only to discover that they're centuries too late! The High Evolutionary devolved all humans into primitive beasts, and devolves the Hulks too!

A-Bomb brings a cute alien aboard the ship despite Hulk's warnings against it. When the alien starts to multiply and take over, A-Bomb lies about disobeying Hulk's order.

The Agents of S.M.A.S.H. returns to Earth with Leader still in their possession even though they were blamed for the destruction of Vista Verde following the incident by Leader's Agents of C.R.A.S.H. They find Vista Verde under the rule of Abomination (who was pardoned and reinstated into the U.S. Army) upon learning this from Mayor Stan and finding Hulkbusters that are under his command. Now the Agents of S.M.A.S.H. must liberate Vista Verde and defeat Abomination before he can use one of Thunderbolt Ross' old weapons in his plan to attack other nations.

While being pursued by the military, the Agents of S.M.A.S.H. go after Leader when he steals all the confiscated weapons from their vault. When Devil Dinosaur is enlarged and let loose by Leader, the Agents of S.M.A.S.H. team up with Spider-Man to stop Devil Dinosaur and restore him to normal size.

A-Bomb starts to doubt his strength as an Agent of S.M.A.S.H. and must learn to use his other attributes against the incredibly strong Xemnu, an intergalactic fighting champion, for the fate of Earth.

The Agents of S.M.A.S.H. are framed by Abomination and evil gamma-powered doppelgangers of themselves for attacking the S.H.I.E.L.D. Tri-Carrier. Upon arriving at the Tri-Carrier as Nick Fury falls unconscious during the attack, the Agents of S.M.A.S.H. fight the Doppplesmashers which are shapeshifting gamma reactor-powered robots created by Leader (who has become Abomination's silent partner). Now the Agents of S.M.A.S.H. must defeat the Dopplesmashers before they use the Tri-Carrier to destroy the Cheyenne Mountain nuclear bunker as a fail-safe and cause World War III.

The Hulks are locked up by Abomination in the same super villain prison where many of their enemies now reside. Can the Hulks escape and prove their innocence?

Upon S.H.I.E.L.D. exonerating them from the frame-up in Vista Verde caused by the Agents of C.R.A.S.H., the Agents of S.M.A.S.H. track the Leader to a deserted island. They get stuck in a deadly maze (which Leader improved on Thunderbolt Ross' plans in his earlier fight with Hulk) where Hulk's rage is drained from him, making him mellowed out. After the rest of his teammates are captured, Hulk finds them in Leader's clutches at the center of the maze where Leader uses his machine to manifest Hulk's dark side in the physical form of Dark Hulk.

Hulk reluctantly fills in as Mayor of Vista Verde while Mayor Stan is on vacation. Red and Skaar leave the team to start their own webcast as super villain bounty hunters - their first target: Abomination. But things get complicated when the Red Ghost and his Super-Apes (consisting of Mikhlo the Gorilla, Igor the Baboon and Peotr the Orangutan) are after Abomination as well as part of a plot to siphon Abomination's gamma energy and make an army of Abomin-Apes.

While saving Earth from a potentially catastrophic meteorite, the Hulks come face to face with a future version of Hulk called Maestro who might not be the hero they think he is. The rest of the Agents of S.M.A.S.H. are unaware of Maestro's true plans until they encounter a future A-Bomb.

The Hulks team up with Hercules to stop Pluto from turning everyone on Earth to stone.

With help from Betty Ross, Hulk allows himself to be turned back into Bruce Banner. Bruce Banner then struggles with the decision when Ronan the Accuser launches a Kree attack on Earth.

The Agents of S.M.A.S.H. help Iron Man subdue Mainframe in a gladiatorial roller derby game for the fate of the planet. However, only one of the Hulks knows how to skate.

Hulk chases Leader back in time to the Jurassic era, but their actions result in present Earth being taken over by dinosaurs! Hulk battles Leader in the past to save all of time.

Hulk follows Leader back in time to the Viking Era and teams up with young Thor and Loki. The Agents of S.M.A.S.H. fight to stop All Father Leader from taking over the planet.

Hulk pursues Leader back in time to the Victorian era and unites the Howling Commandos against Dracula, who wants to shroud the Earth with Leader's gamma cloud.

Chasing Leader through time to World War II, Hulk teams up with a young Captain America to stop Red Skull who becomes Green Skull when enhanced with gamma energy by Leader. In the present, the Agents of S.M.A.S.H. team up with an old Captain America to fight and free the world from HYDRA which is led by Leader and operating a device that is powered by Green Skull.

Finally catching up to the Leader in the present, Hulk reunites with the Agents of S.M.A.S.H. as Leader uses the powers of his time belt to summon paradox monsters from the alternate timelines like a Gamma Dinosaur, a Sauron/Frost Giant hybrid, a Vampire Devil Dinosaur, and the Red Skullasaurus. During the fight with Leader and the paradox monsters, Hulk is unexpectedly whisked into the future by teenage Smashers consisting of Leader's rebellious son Junior, RJ3, and twin siblings Thad and Betts. The 3rd Generation Smashers need Hulk's help battle the threats of L.E.A.D.R. (the consciousness of Leader in a robot body) who plans to replace everyone on Earth with Leader clone versions of themselves while the real humans are placed in the Negative Zone.

While escorting Abomination to stand trial for his crimes, the Hulks run into Ghost Rider, who has come to make both Abomination and Red atone for their past bad deeds.

A Kree armada led by the Supreme Intelligence who is invading in retaliation for Ronan the Accuser's incarceration. When the Kree free Ronan the Accuser and Leader, Hulk is torn between his two teams the Agents of S.M.A.S.H. and the Avengers where both groups fight to prevent the Kree from destroying Earth.

The Agents of S.M.A.S.H. and the Avengers have to work together to free Hulk from the Supreme Intelligence and prevent the destruction of Earth. But it's going to take more than even these heroes to stop the powerful Kree in an all-new MARVEL'S HULK AND THE AGENTS OF S.M.A.S.H. Written by Kevin Riri