A beautiful woman tries to avoid her marshal husband for his own protection, because a gang of robbers is planning on killing him over a robbery he foiled, thanks to her warning. She draws Slim in to help but Jess thinks she is bad luck.

Jess is appointed temporary sheriff of Laramie. Luke Wiley is a notorious, coward, bounty hunter dubbed "The Jackal" because he brings in his prisoners dead, and now he wants to take in a friend of Jess who is wanted for murder.

As the Laramie marshal is killed by the Torrey gang, his new deputy arrives on the stage for Laramie. He and Jess get off on the wrong foot so when he needs a posse, Jesse refuses until a neighbor is killed then new issues arise.

Sam Jarrad, once a bounty hunter but now a sheriff in Colorado, is after the killer of Blake Wilkie. When his prime suspect says Jess did it, Jarrod goes after Jess but he seldom returns with a live prisoner. Slim hopes to change that.

Slim and Jess collect a $2000 bounty on a man they killed after stealing their horse. After collecting the bounty, they learn the dead man is really a sheriff chasing the man they thought they killed who returns to steal the money.

Slim's new hand Joe Cloud, an Indian, is killed by neighbor Carl Vail when he finds Joe skinning his cow with a broken leg. He kills Joe using an Indian method. Slim presses charges against Vail but finds himself ostracized by Laramie.

Jess is forced by a released convict Clint Wade to take him to Utah where Jess killed Clint's brother who hid $80,000 there. Clint thinks Slim is following them to rescue Jess but the it turns out an old cell mate wants the money, too.

When a sick passenger arrives on the stage, Slim and Jess try to help him but are surprised when he is a she. On top of that she is looking for Jess who wants nothing to do with her as her family are all outlaws but Slim thinks otherwise.

Slim's neighbor Cory who is half Cheyenne is thinking about inviting some of his tribe to move to the ranch he inherited from his white father. However, his uncle and cousins have other ideas. Slim wants to help him but Cory is wary.

Jess as acting deputy frees a bounty hunter's prisoner who had cut down Jess during a lynching five years earlier saving his life. Having paid his debt, he decides to see if the prisoner was truly innocent himself or should be recaptured.

Jess finds a starved drifter who thinks Jess wants to shoot him. Slim and Jess offer him a job as he turns out to be a good worker but very reclusive. The father of a man he killed in a fair fight is sending hired guns after him.

A test of friendship is brought to the forefront when Jess learns that an old friend has stolen an Army payroll. He is asked by Major Stanton to find and return veteran Sgt. Billy Jacobs who has gone AWOL but once saved Jess' life.

A prisoner is killed by the son of a broke farmer as they transport him to the tumbleweed wagon for pickup. Needing the $100 for the job the farmer decides to substitute Slim when they find him alone on the road putting Slim in danger.

When Slim holds off outlaws from a gang run by Doc Longley who saved him when he was six, Doc calls on Slim to help clear his name. A deputy shot in the back was planted on his ranch. Slim reluctantly tries to help but there is no proof.

Jess is asked for help by old partner Dixie Howard, who once saved Jess' life, after being wounded and killing a friend of Jess. Dixie is with his beautiful girlfriend but she and Jess soon realize the old Dixie is no more.

With the Sioux attacking the stage, Slim suggests they repair an old road the Sioux will not attack. He has stage driver Lon MacRae gather a work crew which seems to be an odd group of men. When they die one by one, no one knows why.

Slim is sent to renew a lease right of way for the stage line but finds the woman owning the ranch in financial trouble. Her husband was killed and suspected of robbing a $30,000 payroll. Slim decides to help but may be in too deep.