The team celebrates the opening of its new headquarters, finally complete after 10 years of working out of trailers.

In a night filled with multiple shootings, Holly and Nick have to search for a gunshot victim that has gone missing. Meanwhile Titus and Dan tend to a man stabbed multiple times. Keeley is heartbroken about the shooting tragedy in Orlando, and is intent on participating in the city's upcoming pride march.

Working together for years has turned Titus and Dan into great friends. But on their shift, they inevitably come across folks who are the victims of crimes perpetuated by those closest to them. It's on calls like these when they become more than just emergency medical technicians; they're also therapists and counselors, doing whatever they can to steer some troubled people back in the right direction.

Every night, the members of the Nightwatch in New Orleans are reminded in new ways to be thankful for what they have. This shift is no exception. EMT's Titus and Dan resuscitate an overdosing drug user just before all hope is lost; Brooke and Landon tend to a young girl with congenital heart issues; and a team of fire fighters contain a fire before it can wreak havoc. Then things get a little lighter when Titus and Dan learn a familiar patient is also a secret admirer of Holly.

On Nightwatch not all tragedies are created equal and tonight, when the men and women serving New Orleans get word that one of their own has been critically injured, they reflect on the risks they all take. The other calls of then night mirror that reality - including a scene where a small party was thrown into chaos by armed intruders, and a bar where a fight ended with a good Samaritan getting seriously wounded while trying to break it up.

As Titus puts it, When one of us gets hurt, we feel like all of us are hurt. And in New Orleans on the Nightwatch, every call isn't just about a victim whose life is in danger, or even a criminal who's broken the law. It's about people serving people. In several calls - from a restaurant in the French Quarter to a car accident uptown - bystanders chip in to help the first responders. There's also a tourist who has to be coaxed to the hospital, and a rapper whose spotless record belies his style. In every case, the members of the Nightwatch offer southern hospitality, New Orleans style.

On a hot, humid night in New Orleans, there's no escaping the temperatures as tempers rise and violence swells. The police chase two armed carjacking suspects; Keeley tends to an injured young family in a car accident; and Titus and Dan answer a call from a woman who turns out to be a former Playboy bunny.

If every night in New Orleans is an adventure, this one is filled with characters in situations unlike any other. A woman in a disagreement with her boyfriend tells police he once brought her back to life after she was murdered; a purse-snatching suspect stops running away from authorities so he can finish eating some chicken strips; and a tarot card reader gets dehydrated after a long day working on Bourbon Street.

As anyone in New Orleans could tell you, when times are toughest, family and friends are more important than anything in the world.

Every call on the Nightwatch can go in one of two directions. And when the calls come from every direction.

An in-depth look at what it is like to be an officer patrolling the streets of New Orleans today. The one-hour special will explore what motivates the officers to do this job and the realities of what they experience on a nightly basis.