Everything's changing for Danielle and Adam Busby, as America's first and favorite all-female quintuplets grow from babies to big girls.

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When Danielle catches the flu, Mimi struggles to take care of 5 babies on her own. Adam plans a 10-year anniversary surprise for Danielle. And later, when Danielle gives a speech for the hospital, she faces the painful past of having premature babies.

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After Danielle confronts Adam about his money spending ways, they realize they need to make some tough choices to provide for their six girls. They also continue to step up their efforts to get Hazel walking so she can join her sisters in pre-school.

It's Halloween, but before the Busbys can celebrate the Quints' first trick-or-treat outing, they must race to find costumes, shop for pumpkins and get the new house ready for a Halloween party, all while making a final decision on a $100,000 investment.

It's the quints' first family vacation! But with five toddlers running wild, it may feel more like work than vacation time for Adam and Danielle. Meanwhile, Adam struggles to tell his brother-in-law, and boss, about the new business he's starting.