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The Busbys plan a very special Thanksgiving, but bad news for Mimi may throw the holiday into turmoil. When Adam and Danielle find out that Riley and Parker are moving up to a different classroom, Adam struggles with the idea of separating the quints.

The Busbys wade back into the world of potty training, determined not to be defeated this time. Blayke takes gymnastics lessons and enjoys one-on-one time with her parents. Mimi distances herself from the family as she struggles with the loss of her house.

After getting bad news about Hazel, Danielle's determined to make this the best Christmas ever. But Adam has different plans for the holiday, which may sour the celebration. The quints perform in the Christmas show, but stage fright may take center stage.