Hank treats a politician who does not want to slow down her campaign to take care of her health. Jeremiah needs Divya's help when his first patient after returning from sabbatical proves to be challenging. Hank and Evan react very differently when Eddie returns to the Hamptons with a surprise announcement, and Divya's plans for her future hit a roadblock.

Hank treats a stuntwoman on the set of a film that's said to be cursed. Evan deals with the fallout from the cyber attack on Hamptons Heritage as Diana Underhill's hacked medical records become national news. When Jeremiah's parents come to town, Divya helps the family work through their differences. Meanwhile, Hank and Jen go on their first date but things don't go as planned.

Hank finds romance in Hong Kong while preventing the theft of Boris's medical records. Divya treats a repo man bent on taking back a yacht. Paige convinces Evan to rethink their parenting path.

In the 100th episode, Hank works a shift in the ER for the first time in years. Jill makes a surprise visit to the Hamptons. Jeremiah bonds with a patient he secretly admires, and Divya worries for a patient.

A visit to his old mentor and a serious diagnosis for agent Ken Keller cause Hank to rethink his future. Evan struggles to be more supportive as Paige tries to get pregnant. Jeremiah tries to shoot a video for Divya's baby shower.

Hank meets a woman who fears she has an inherited disease. Eddie makes a medical decision without consulting Hank. Jeremiah learns that Boris went to clinical trials without his input.

Hank helps a theater legend as she deals with confusion and memory loss at Eddie's wedding. He also reconciles Eddie and Evan before the ceremony. Paige and Evan await pregnancy test results.

HankMed temporarily dissolves as each important player in the business is off to bigger and better things--except for Hank, who still has no idea what the future holds for him.