The Alienist opens when a series of haunting, gruesome murders of boy prostitutes grips New York City. Newly appointed police commissioner Theodore Roosevelt (Geraghty) calls upon criminal psychologist (aka alienist) Dr. Laszlo Kreizler (Brühl) and newspaper illustrator John Moore (Evans) to conduct the investigation in secret. They are joined by Sara Howard (Fanning), a headstrong secretary determined to become the city's first female police detective. Using the emerging disciplines of psychology and early forensic investigation techniques, this band of social outsiders set out to find and apprehend one of New York City's first serial killers.

The Alienist opens when a series of haunting, gruesome murders of boy prostitutes grips New York City. Newly appointed police commissioner Theodore Roosevelt (Geraghty) calls upon criminal psychologist (aka alienist) Dr. Laszlo Kreizler (Brühl) and newspaper illustrator John Moore (Evans) to conduct the investigation in secret. They are joined by Sara Howard (Fanning), a headstrong secretary determined to become the city's first female police detective. Using the emerging disciplines of psychology and early forensic investigation techniques, this band of social outsiders set out to find and apprehend one of New York City's first serial killers.

The Alienist opens when a series of haunting, gruesome murders of boy prostitutes grips New York City. Newly appointed police commissioner Theodore Roosevelt (Geraghty) calls upon criminal psychologist (aka alienist) Dr. Laszlo Kreizler (Brühl) and newspaper illustrator John Moore (Evans) to conduct the investigation in secret. They are joined by Sara Howard (Fanning), a headstrong secretary determined to become the city's first female police detective. Using the emerging disciplines of psychology and early forensic investigation techniques, this band of social outsiders set out to find and apprehend one of New York City's first serial killers.

Sara and Kriezler posit on the ability to kill. Moore goes on a date. Byrnes and Connor eye potential suspects. Roosevelt is under scrutiny from the public.

The team build a profile for the killer. Moore and Sara share an intimate moment. Kreizler gets advice from an old mentor. Roosevelt finally takes action.

The team set a trap to catch the killer. Moore visits a friend. Kreizler is filled with self-doubt over the investigation. Roosevelt is part of an event with the city elite. Sara looks into Kriezler's past.

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Kreizler and Moore travel to DC. Sara goes rogue in her pursuit of the truth. Lucius confides a secret to Marcus. Byrnes and Connor tighten their stranglehold on the investigation.

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Kreizler confronts the demons of his past. Moore tell Sarah the truth. Conner takes matters into his own hands. The team closes in on the killer as time is running out.