A young woman's body is found in the Arizona desert, while over 2,500 miles away, a young man worries about his missing sister; an investigation into her death begins, and it will take decades to reveal her name and her killer.

Not long after a jogger discovers a woman's body off a remote road in Pennsylvania, a family worries when the godmother never shows up to a baptism. A frantic search begins for a missing woman that leads investigators up and down the east coast.

An unidentified woman's body surfaces in the warm waters of the Gulf of Mexico; meanwhile, a woman vanishes from her new home in Florida, then, nearly 30 years later, both tales are untangled to reveal a story of love, loss, life, and death. Written by Sirens Media

The body of a beautiful woman is found in the Pennsylvania woods, and it's clear her death is no accident. A decade-spanning investigation begins, and officials are determined to discover this woman's name and bring her home.

In October 2005, on her youngest son's 7th birthday, Pamela Knight vanishes. Years later, two men run across the remains of a woman buried under an abandoned shed. It will take seven years and a prison row confession to find out what happened.

A heartbroken woman waits for her daughter to come home for the holidays, but she never does; in another state, investigators find a woman's remains, and these two seemingly unrelated incidents come together as investigators finally catch a break. Written by S. Kozak

Behind the discovery of every Jane Doe lie two stories: the story of the detectives puzzling together her identity, and the story of her family that has now lost her forever. This series weaves the two stories together, taking viewers on a unique journey of discovery, loss, and resolution, challenging the perception of how we tell crime stories and parcel out information. Written by Sirens Media